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The AcuteTox partner Dr. Richard Clothier, receives the Bjorn Ekwall Memorial Award 2010

The AcuteTox partner Dr. Richard Clothier, receives the Bjorn Ekwall Memorial Award 2010, in recognition of his outstanding contributions in the field of in vitro toxicology, and in particular with respect to the development, implementation and validation of alternative toxicity test methods, and for his substantial contribution to the Fund for the Replacement of Animals in Medical Experiments (FRAME) Research Programme.

Richard was a co-founder (in 1983) of the FRAME Alternatives Laboratory (FAL) at the University of Nottingham Medical School, and was the director of the FAL from 1997 to 2005. He has played a substantial role in the field of in vitro toxicology, by contributing to the development and application of alternative assays for replacing animal toxicity testing, e.g. the Neutral Red Uptake (NRU) and Neutral Red Release (NRR) tests for basal cytotoxicity, the Fluorescent Leakage assay, the Alamar Blue (Resazurin) metabolism test for toxicity, and many others.  

As an expert in national and international trials, he has contributed significantly to the further advancement of the acceptance of alternative assays for toxicity through his commitment to a number of studies, including a FRAME-led study in 1983 - 1986, the EC/HO and COLIPA international validation study on alternatives to the Draize eye irritation test, the EU/COLIPA international validation study on the in vitro 3T3 NRU test for phototoxicity, and the ECVAM/ICCVAM assessment of the NRU assay for measuring basal toxicity.

 

The award will be handed over at the 2010 FRAME Annual Lecture at The Kennel Club in London the 4th of November.