Human in vivo database

 

Nearly 2800 human cases have been compiled for 97 reference chemicals, comprising three categories of single dose exposure at acute poisoning, each with or without time information: sub-lethal, lethal, and post-mortem. Availability of human cases was frequently limited by improbable occurrence of acute human exposure (i.e., accidental ingestion, suicidal overdose, etc.) and/or unknown clinical/forensic monitoring of a patient/victim with reported blood concentration measurements. In particular, eleven reference chemicals remain without any reported acute poisoning cases.

 

The main sources of data were international journals, toxicology handbooks, MEIC monographs, Swedish Poison Information Centre, Gottingen (Germany) Poison Information Centre, Poisindex, Thomson Micromedex, and several on-line databases (e.g. HSDB, ChemPlus, RTECS etc.). Each case of poisoning is provided by age and sex of a victim, type of poisoning  (intentional or unintentional), toxic dose of chemical, time (exposure to sumpling), blood concentration of chemical, symptoms and signs of poisoning, as well as the treatment of a poisoned person.

 

All reported cases are listed in separate tables for each ACuteTox reference chemical (links in 1st column in the table below). Links to the references are found in the 2nd column of the table. Links to short descriptions of each ACuteTox reference chemical, containing information on toxicity, kinetics, etc. are found in the 3rd column of the table. Abbreviations used in tables below are found here.

 

Fore more information and questions on the human in vivo database contact Ada Kolman: ada.kolman2@gmail.com.  

 

Table. Links to case reports, references and short description for all ACuteTox reference chemicals.

 

Tables human cases References Short descriptions Drug Industrial Biocide Other
Acetaminophen 1 Acetaminophen +      
Acetylsalicylic acid 2 Acetylsalicylic acid +      
Atropine 3 Atropine +      
Caffeine 4 Caffeine +      
Carbamazepine 5 Carbamazepine +      
Colchicine 6 Colchicine +      
Cycloheximide 7 Cycloheximide     +  
Diazepam 8 Diazepam +      
Digoxin 9 Digoxin +      
Isopropyl alcohol 10 Isopropyl alcohol   +    
Malathion 11 Malathion     +  
Mercury(II)chloride 12 Mercury(II)chloride   +    
Pentachlorophenol 13 Pentachlorophenol   + +  
Phenobarbital 14 Phenobarbital +      
Sodium lauryl sulfate 15 Sodium lauryl sulfate   +    
Sodium valproate 16 Sodium valproate +      
5-fluorouracil 17 5-fluorouracil +      
Benzene 18 Benzene   +    
Tert-butylhydroperoxide 19 Tert-butylhydroperoxide   +    
Acrylaldehyde 20 Acrylaldehyde   +    
Cadmium(II)chloride 21 Cadmium(II)chloride   +    
Phenanthrene 22 Phenanthrene       + 1)
Pyrene 23 Pyrene   +    
1,2,3,4-tetrachlorobenzene 24 1,2,3,4-tetrachlorobenzene   +    
Pentachlorobenzene 25 Pentachlorobenzene   +    
Hexachlorobenzene 26 Hexachlorobenzene   +    
Benz(a)anthracene 27 Benz(a)anthracene       + 2)
Amiodarone 28 Amiodarone +      
Verapamil 29 Verapamil +      
Rifampicine 30 Rifampicine +      
Tetracycline  31 Tetracycline  +      
Orphenadrine 32 Orphenadrine +      
Nicotine 33 Nicotine +      
Lindane 34 Lindane     +  
Amphetamine 35 Amphetamine +      
Methadone 36 Methadone +      
Ethanol 37 Ethanol   +   + 3)
Parathion 38 Parathion     +  
Dichlorvos 39 Dichlorvos     +  
Physostigmine 40 Physostigmine +      
Glufosinate 41 Glufosinate     +  
Cisplatinum 42 Cisplatinum +      
Diethylene glycol 43 Diethylene glycol   +    
Diquat 44 Diquat     +  
Ochratoxin A 45 Ochratoxin A       + 4)
Cyclosporine A 46 Cyclosporine A +      
17a-ethynylestradiol 47 17a-ethynylestradiol +      
Sodium fluoride 48 Sodium fluoride +      
Paraquat 49 Paraquat     +  
Glycerol 50 Glycerol   +    
Dimethylformamide 51 Dimethylformamide   +    
Iron(II)sulfate 52 Iron(II)sulfate   +    
Amitryptiline 53 Amitryptiline +      
Ethylene glycol 54 Ethylene glycol   +    
Methanol 55 Methanol   +    
Phenol 56 Phenol   +    
Sodium chloride 57 Sodium chloride       + 5)
Xylene 58 Xylene   + +  
Potassium cyanide 59 Potassium cyanide   +    
Lithium sulfate 60 Lithium sulfate   +    
Theophylline 61 Theophylline +      
Haloperidol 62 Haloperidol +      
Propranolol 63 Propranolol +      
Arsenic trioxide 64 Arsenic trioxide +      
Thioridazine 65 Thioridazine +      
Thallium sulfate 66 Thallium sulfate     +  
Warfarin 67 Warfarin +      
Chloroform 68 Chloroform   +    
Isoniazid 69 Isoniazid +      
Dichloromethane 70 Dichloromethane +      
Hexachlorophene 71 Hexachlorophene     + 6)  
Chloroquine diphosphate 72 Chloroquine diphosphate +      
5,5-diphenylhydantoin 73 5,5-diphenylhydantoin +      
Chloramphenicol 74 Chloramphenicol +      
Potassium chloride 75 Potassium chloride + +    
Chloral hydrate 76 Chloral hydrate +      
2,4-dichlorophenoxyacetic acid 77 2,4-dichlorophenoxyacetic acid     +  
Meprobamate 78 Meprobamate +      
Sodium pentobarbital 79 Sodium pentobarbital +      
Strychnine 80 Strychnine       + 7)
Glutethimide 81 Glutethimide +      
Maprotiline 82 Maprotiline +      
Disopyramide 83 Disopyramide +      
Diphenhydramine 84 Diphenhydramine +      
Chlormethiazole 85 Chlormethiazole +      
Quinidine 86 Quinidine +      
Procainamide 87 Procainamide +      
Codein 88 Codein +      
Chloropromazine 89 Chloropromazine +      
Paraldehyde 90 Paraldehyde +      
Sodium selenate 91 Sodium selenate   +    
Acetonitrile 92 Acetonitrile   +    
Sodium bicarbonate 93 Sodium bicarbonate + +    
Acrylamide 94 Acrylamide   +    
Formaldehyde 95 Formaldehyde   +    
Epinephrine 96 Epinephrine +      
Acetaldehyde 97 Acetaldehyde   +    

 

 

1)      environmental contaminant

2)      laboratory chemical

3)      component of alcohol beverages

4)      environmental toxin of bacterial origin

5)      food component

6)      antibacterial biocide; other chemicals in the same column are pesticides and/or insecticides

7)      poison

 

 

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